Vascular effects of quinapril completely depend on ACE insertion/deletion polymorphism

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Vascular effects of quinapril completely depend on ACE insertion/deletion polymorphism.

INTRODUCTION The angiotensin-converting enzyme (ACE) DD-genotype is associated with increased plasma and myocardial ACE-activity. The influence of the ACE insertion/deletion (I/D) polymorphism on the effects of ACE-inhibition on vascular responses has not been previously described. MATERIALS AND METHODS In the randomised, double-blind QUinapril On Vascular ACE and Determinants of Ischemia Stu...

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Angiotensin II and nitric oxide (NO) may play a role in hypertensive cardiovascular remodeling. We evaluated the effects of long-term treatment with quinapril, an angiotensin converting enzyme (ACE) inhibitor, on expression of endothelial NO synthase (eNOS), ACE, and angiotensin II type 1 (AT1) receptor in the left ventricle and evaluated these relations to myocardial remodeling in deoxycortico...

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ژورنال

عنوان ژورنال: Journal of the Renin-Angiotensin-Aldosterone System

سال: 2004

ISSN: 1470-3203,1752-8976

DOI: 10.3317/jraas.2004.029